Regulation of T-cell-mediated lympholysis by the murine major histocompatibility complex. II. Control of cytotoxic responses to trinitrophenyl-K and -D self products by H-2K- and H-2D-Region genes.

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Abstract
An H-2K/IA recombinant mouse strain was used to map the genes within the H-2 complex which determine the ability to respond in cell-mediated lympholysis (CML) to low doses of trinitrophenyl-self (TNP-self). Gene(s) which map to the K region involved in regulation of CML response to low-dose TNP-self. CML response to TNP recognize in association with H-2Dq was not detectable in this recombinant. Findings are discussed with respect to the involement of the H-2K and H-2D regions by structural and/or regulator gene functions.

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