CROSS-REACTIVITY AMONG THE PRODUCTS OF THREE NONALLELIC H-2 LOCI, H-2Ld, H-2Dq, AND H-2Kk

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Abstract
Cross-reactions of the products of 3 nonallelic H-2 loci, H-2K, H-2D, and H-2L, were studied by serological, immunochemical, and cellular immune techniques. Immunoprecipitation experiments revealed a determinant shared between Ld and Dq molecules but absent on Dd molecules. By cytotoxic screening of sera from individual mice an exceptional anti-Ld serum was found which cross-reacted with an H-2k antigen. Genetic mapping studies suggested that the basis of this activity was an Ld-Kk serological cross-reaction. Cytotoxic T [thymus-derived] cells generated to Ld alloantigens also recognized a cross-reacting Kk determinant. L, D, and K appear to be 3 structurally homologous cell surface glycoproteins that have evolved from a common primordial gene.