Phenypressin (Phe2-Arg8-vasopressin), a new neurohypophysial peptide found in marsupials

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Abstract
Recent investigations on marsupial neurohypophyseal hormones have revealed that species belonging to the Australian family Macropodidae and the American family Didelphidae have, apart from an oxytocin-like hormone, 2 vasopressin-like peptides which can be separated either by ion-exchange chromatography or chromatoelectrophoresis. The major pressure hormone of 2 Australian species, the red kangaroo (Macropus rufus) and the tammar (Macropus eugenii), was identified as lysine vasopressin by its amino acid sequence and its pharmacological properties. The minor pressor hormone, which chromatographs on Amberlite CG-50 like arginine vasopressin, differs from it in sequence only at position 2 where phenylalanine replaces the tyrosine of arginine vasopressin.