QUANTITATIVE EFFECTS OF IMMEDIATE ANTITHROMBINS

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Abstract
A direct relation exists between the clotting-time (thrombin + fibrinogen-containing fluids) and the cone, of inhibitors (electrolytes or heparin plus co-factor). The rate of increase of clotting-time with increasing cones, of these antithrombins, i.e., the inhibition slope, varies inversely with the thrombin cone. The principles of new methods for the assay of thrombin and immediate antithrombins are outlined. K ferrocyanide is suggested as a reference standard for the latter. A clot acceleration effect produced by traces of immediate antithrombins, or, occasionally, by dilution, is observed with plasma and with some thrombin preps.

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