Atherosclerosis: AnIn VitroStudy of the Pathogenesis of Atherosclerosis

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Abstract
Blood samples from normal young adults and from cases of myocardial infarction and of diabetics with vascular disease were pulsated 80 times/min. against strips of fresh normal human aorta from cadavers for 72 hrs. at pressures of 300/0 mm. Hg. The equipment designed to accomplish this is descr. At the end of each expt., the aortic strips were fixed, and frozen sections were stained for fat and examined under normal and polarized light. Deposits of birefringent particulate material were found in the wall of 75% of the aortic strips pulsated with blood from patients with cardiovascular disease, but only 4.5% of the strips pulsated with healthy blood had any deposits and they were very slight. The aortic strips in the "positive" group closely resembled similar prepns.- from early cause of atheroma with regard to the deposition of birefringent particles.