Activity of NMN+, nicotinamide ribose and analogs in alcohol oxidation promoted by horse‐liver alcohol dehydrogenase
- 3 March 1986
- journal article
- research article
- Published by Wiley in European Journal of Biochemistry
- Vol. 155 (2) , 403-407
- https://doi.org/10.1111/j.1432-1033.1986.tb09505.x
Abstract
Kinetic constants of horse‐liver alcohol‐dehydrogenase‐mediated oxidation of alcohol by nicotinamide mononucleotide and nicotinamide ribose were determined and the role of different adenine moieties complementing the reaction mixtures was investigated. Five nicotinamide ribose analogs were synthesized and their activities as NAD+ inhibitors and as cofactors in this dehydrogenase‐mediated oxidation of alcohol were assayed. In the light of these results, structural requirements of the pyridine ribofuranosyl part of the NAD+ are discussed.This publication has 17 references indexed in Scilit:
- A new approach for using cofactor dependent enzymes: example of alcohol dehydrogenaseFEBS Letters, 1984
- Comparison of the alkylation of nicotinamide and 4-(p-nitrobenzyl)pyridine for the determination of aliphatic epoxidesAnalytical Chemistry, 1982
- Carbocyclic sugar amines: synthesis and stereochemistry of racemic .alpha.- and .beta.- carbocyclic ribofuranosylamine, carbocyclic lyxofuranosylamine, and related compoundsThe Journal of Organic Chemistry, 1981
- Structure of a triclinic ternary complex of horse liver alcohol dehydrogenase at 2.9 Å resolutionJournal of Molecular Biology, 1981
- Synthesis of Glycosides of Nicotinamide and Nicotinamide MononucleotideSynthesis, 1981
- Unified Mechanism for Proton‐Transfer Reactions Affecting the Catalytic Activity of Liver Alcohol DehydrogenaseEuropean Journal of Biochemistry, 1980
- The Crystal Structure of Complexes between Horse Liver Alcohol Dehydrogenase and the Coenzyme Analogues 3‐Iodopyridine‐adenine Dinucleotide and Pyridine‐adenine DinucleotideEuropean Journal of Biochemistry, 1977
- Three-dimensional structure of horse liver alcohol dehydrogenase at 2.4 Å resolutionJournal of Molecular Biology, 1976
- Conversion of acyclic carbohydrates to tetrahydrofuran derivatives. Deamination of 1-amino-1-deoxypentitolsThe Journal of Organic Chemistry, 1970
- Zur Darstellung von Derivaten des NicotinsäureamidsEuropean Journal of Organic Chemistry, 1953