Spontaneously metastasizing variants derived from MNU-induced rat mammary tumour
Open Access
- 1 April 1982
- journal article
- research article
- Published by Springer Nature in British Journal of Cancer
- Vol. 45 (4) , 588-597
- https://doi.org/10.1038/bjc.1982.96
Abstract
N-methyl-N-nitrosourea (MNU) given i.v. to female rats of inbred strains induces mammary adenocarcinomas which are hormone-sensitive but do not spontaneously metastasize (Williams et al., 1981). Tissue culture and selection techniques have been used to derive metastasizing tumours from a mammary tumour induced with MNU in F344/N rats. Histologically, primary tumours and metastases in the lung and lymph nodes were similar. These systems may constitute useful models for the study of breast-cancer metastasis.Keywords
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