Some Pharmacological Characteristics of Bacitracin III. Chronic Toxicity Studies of Commercial Bacitracin in the Dog and Monkey.

Publisher Website
Google Scholar
Abstract
Following prolonged daily admn. of crude bacitracin concentrates in dogs and monkeys, no significant changes in blood morphology were observed. Injn. of bacitra-cin soln. (6000 units /ml.) into the shaved abdominal skin, and instillation of bacitracin (1200 units /ml.) into the con-junctival sac of the rabbit caused little irritation. Repeated intramusc. injn. of 1000 units of bacitracin / kg. 3 times daily for 23 days into the dog produced local induration; 1500 units / kg. twice daily for 45 days in the same area in monkeys produced both induration and small areas of necrosis. In the dog, urine samples remained negative for sugar and albumin while in the monkey, sugar and albumin appeared in the urine as the animals continued on test. Large doses of bacitracin approximating the LD50, produced damage to the renal tubules, with tubular necrosis in the mouse. In the rat and the dog, the lesions were insignificant, while in the monkey, necrotic cells were found in 2 instances only, and then in comparatively insignificant numbers as contrasted with the mouse.

This publication has 2 references indexed in Scilit: