Chronic Allograft Rejection in the Iguana Ctenosaura pectinata

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Abstract
Adult male and female iguanas, C. pectinata, were auto- and allografted. Skin allografts and autografts behaved like those of other vertebrates; they healed in initially but allografts later showed signs of rejection recognized mainly by pigment cell destruction. At 25[degree]C chronic rejection of 1st-set allografts in the iguana, as indicated by the survival times, is more like the rejection pattern of urodeles and apodans than that of anuran amphibians or fishes. Allograft rejection is by an immune process since accelerated rejection of some 2nd-set grafts occurred while the rest showed enhanced survival. In addition, an inflammatory response, characterized by lymphcytic infiltration, was always associated with destroyed grafts.