Circulating immune complexes in ulcerative colitis. I. Correlation to disease activity.

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  • 1 January 1978
    • journal article
    • Vol. 31  (1) , 72-80
Abstract
Twenty-two patients with ulcerative colitis were studied for occurrence of circulating immune complexes (IC) by three independent methods, a complement consumption assay, a Clq-binding assay and a RF-binding assay. All patients had the disease in an active stage when the study was initiated. Positiveness in two or more test systems was considered to indicate the presence of IC in the serum sample examined. By this criterion, circulating complement-fixing IC were detected in eight out of the twenty-two patients (36%; 95% confidence limits: 17–60%). IC were detected most frequently in patients with long-standing disease.