New Bisindole Alkaloids of the Topsentin and Hamacanthin Classes from the Mediterranean Marine Sponge Rhaphisia lacazei
- 15 March 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (4) , 447-451
- https://doi.org/10.1021/np9903292
Abstract
Chemical investigation of the Et2O extract of the marine sponge Rhaphisia lacazei resulted in the isolation of 13 pure bisindole alkaloids (1−13). Compounds (1−6) belong to the class of topsentins and have already been described. Compounds 7−13 are new products, closely related to the class of hamacanthins. The major compounds 1−3 were tested in vitro for antitumor activity; compounds 2 and 3 showed antiproliferative activity against human broncopulmonary cancer cells (NSCLC-N6) with an IC50 of 12 and 6.3 μg/mL, respectively.Keywords
This publication has 13 references indexed in Scilit:
- Brominated Indole Alkaloids from the Marine Tunicate Pseudodistoma arborescensJournal of Natural Products, 1993
- Marine natural productsNatural Product Reports, 1993
- A new bis-(indole) alkaloid from a deep-water marine sponge of the genus SpongosoritesThe Journal of Organic Chemistry, 1992
- Marine natural productsNatural Product Reports, 1992
- 6-Bromotryptamine Derivatives from the Gulf of California Tunicate Didemnum candidumJournal of Natural Products, 1991
- Marine natural productsNatural Product Reports, 1991
- Nitrogenous metabolites from the deep water sponge Hexadella sp.Canadian Journal of Chemistry, 1989
- Topsentin, bromotopsentin, and dihydrodeoxybromotopsentin: antiviral and antitumor bis(indolyl)imidazoles from Caribbean deep-sea sponges of the family Halichondriidae. Structural and synthetic studiesThe Journal of Organic Chemistry, 1988
- Photoisomerization of some N-aryl .alpha.,.beta.-unsaturated iminium saltsThe Journal of Organic Chemistry, 1988
- Topsentins, new toxic bis-indole alkaloids from the marine sponge TopsentiagenitrixCanadian Journal of Chemistry, 1987