ON THE SIMULTANEOUS ACTION OF TWO COMPETITIVE ANTAGONISTS
Open Access
- 1 June 1974
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 51 (2) , 287-300
- https://doi.org/10.1111/j.1476-5381.1974.tb09659.x
Abstract
1 A hypothesis is outlined predicting the conditions in which the addition of a second competitive antagonist will increase rather than reduce the response to an agonist. 2 Experiments were performed with the guinea-pig ileum as the test tissue, hexyltrimethyl ammonium as the agonist, benzilyltropine methiodide as the ‘slow’ antagonist and pentyltriethyl ammonium as the ‘fast’ antagonist. 3 The results are consistent with the hypothesis, if the affinity constant for hexyltrimethyl ammonium is between 2.7 and 3.7 × 104 m−1, if the dissociation time constant for the slow antagonist is greater than 10 min and if that for the fast antagonist is less than 10 seconds.Keywords
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