Potential Pharmaceutical Applications of a New Beta Cyclodextrin Derivative

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Abstract
The three major natural cyclodextrins viz alpha, beta and gamma, consist of six, seven or eight glucose units, respectively (1). In addition to the natural cyclodextrins, numerous new products have been shown to have potential for the pharmaceutical industry (2,3). A clear distinction has to be made between cyclodextrin polymers, which are mainly used as separation materials in analytical chemistry (4) and cyclodextrin derivatives, which are monomers of substituted cyclodextrins (5). In the synthesis process of the latter, both the C(2) and C(3) secondary and the C(6) primary hydroxyl groups have been the target of many chemical substitutions (6), leading to the development and the characterization of cyclodextrin derivatives of pharmaceutical interest (7). Such derivatives have been successfully used in the design of new drug carrier systems (3,5), Hence, in addition to their increased solubility, these chemically modified cyclodextrins exhibit excellent complexing abilities (8). The different possibilities of modifying cyclodextrins have been reviewed by Sebille (2), Szejtli (1) and Uekama (3). Szjetli also published an extensive list of the major cyclodextrin derivatives under investigation until 1982 (1).