Elevated concentrations of substance p and 5-HT in plasma in patients with carcinoid tumors

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Abstract
Ten patients with metastatic carcinoid tumors in the liver showed elevated 5‐hydroxytryptamine and substance P levels in plasma samples taken from hepatic or peripheral veins. Chromatographic characterization of the substance P‐immunoreactivity showed that by gel permeation and high pressure liquid chromatography the substance P‐immunoreactivity was indistinguishable from synthetic undecapeptide substance P. The results suggest that substance P, in addition to the 5‐hydroxyinoles, may serve as a circulatory marker for some forms of carcinoid tumors.