INHIBITION OF POLYMORPHONUCLEAR LEUKOCYTE ADHERENCE BY PROSTACYCLIN

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 95  (5) , 672-678
Abstract
The adherence of human PMN [polymorphonuclear leukocytes] to nylon fibers or endothelial cells was inhibited by exposure in vitro of the phagocytic cells to PG[prostaglandin]I2. The impaired adherence was transient and correlated with a rise in intracellular levels of cyclic AMP. Stimulation of human endothelial cells with sodium arachidonate, a precursor of PGI2, led to impaired PMN adherence. PGI2 failed to alter O2- release and the bactericidal capacity of the PMN. PGI2 may play a role in regulating PMN adhesiveness to endothelial cells without compromising host defense.