Inhibition of Cinchophen Ulcer in Chicks with Boiled Potassium Hydrogen Saccharate

Publisher Website
Google Scholar
Abstract
Simultaneous feeding of saccharic acid lactone (1 1/2% of the diet) with cinchophen prevented completely the usual gastric ulcer formation up to the 10th day at which time the control group treated only with cinchophen had an ulcer in 60 per cent of the cases. At the 14th day the control group had ulcers in 85 per cent, whereas the saccharic acid treated group had ulcers and erosions in 55 per cent. Saccharic acid is known as a β‐glucuronidase enzyme inhibitor. The results are discussed in light of the possible relationship of the local glucuronide conjugation reactions and cinchophen ulcer mechanisms.