Influence of endocrine and chemical factors on glucagon-induced thermogenesis in brown adipocytes.

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Abstract
The thermogenic response of [rat] brown adipocytes to glucagon was reduced by either thyroidectomy or adrenalectomy, while that to noradrenaline [norepinephrine] was not affected. Polyamines (spermine and spermidine) inhibited glucagon-induced thermogenesis of the cells. Glucagon stimulates brown adipocytes under the influence of thyroidal and adrenal hormones, and polyamines regulate the thermogenesis of brown adiocytes in an inhibitory way.