The structure of the complex between influenza virus neuraminidase and sialic acid, the viral receptor
- 1 November 1992
- journal article
- research article
- Published by Wiley in Proteins-Structure Function and Bioinformatics
- Vol. 14 (3) , 327-332
- https://doi.org/10.1002/prot.340140302
Abstract
Crystallographic studies of neuraminidase–sialic acid complexes indicate that sialic acid is distorted on binding the enzyme. Three arginine residues on the enzyme interact with the carboxylate group of the sugar which is observed to be equatorial to the saccharide ring as a consequence of its distorted geometry. The glycosidic oxygen is positioned within hydrogen-bonding distance of Asp-151, implicating this residue in catalysis.Keywords
This publication has 30 references indexed in Scilit:
- Refined crystal structure of the influenza virus N9 neuraminidase-NC41 Fab complexJournal of Molecular Biology, 1992
- Three-dimensional structure of the neuraminidase of influenza virus A/Tokyo/3/67 at 2·2 Å resolutionJournal of Molecular Biology, 1991
- Refined atomic structures of N9 subtype influenza virus neuraminidase and escape mutantsJournal of Molecular Biology, 1991
- Lysozyme revisited: Crystallographic evidence for distortion of an N-acetylmuramic acid residue bound in site DJournal of Molecular Biology, 1991
- Crystallographic refinement by simulated annealingJournal of Molecular Biology, 1988
- Site-directed mutagenesis of β-galactosidase (E. coli) reveals that tyr-503 is essential for activityBiochemical and Biophysical Research Communications, 1988
- Crystallographic determination of the mode of binding of oligosaccharides to T4 bacteriophage lysozyme: Implications for the mechanism of catalysisJournal of Molecular Biology, 1981
- Mechaism of Arthrobacter sialophilus neuraminidase: The binding of substrates and transition-state analogsBiochemical and Biophysical Research Communications, 1978
- Theoretical studies of enzymic reactions: Dielectric, electrostatic and steric stabilization of the carbonium ion in the reaction of lysozymeJournal of Molecular Biology, 1976
- Neuraminidase: the specific enzyme of influenza virus and Vibrio choleraeBiochimica et Biophysica Acta, 1957