Heparin-binding growth factor/prostatropin attenuates inhibition of rat prostate tumor epithelial cell growth by transforming growth factor type beta
- 1 March 1988
- journal article
- rapid communications-in-cell-biology
- Published by Springer Nature in In Vitro Cellular & Developmental Biology
- Vol. 24 (3) , 243-246
- https://doi.org/10.1007/bf02623554
Abstract
Summary Normal rat prostate epithelial cell growth requires both epidermal growth factor and heparin-binding growth factor/prostatropin. In contrast, epithelial cells derived from the transplantable Dunning R3327H rat tumor require either epidermal growth factor or heparin-binding growth factor/prostatropin. Transforming growth factor type beta inhibited normal epithelial cell growth. Transforming growth factor beta inhibited epidermal growth factor-dependent growth of tumor epithelial cells, independent of epidermal growth factor concentrations. Transforming growth factor beta increased the effective dose of heparin-binding growth factor type 1 required to support tumor epithelial cell growth by 10-fold but saturating levels of heparin-binding growth factor type 1 (290 pM) completely attenuated the inhibitory effect of transforming growth factor beta. These results suggest that prostate tumor epithelial cells may escape the inhibitory effect of transforming growth factor beta as a consequence of alteration of the concurrent requirement for both epidermal growth factor (or homologues) and heparin-binding growth factors.Keywords
This publication has 13 references indexed in Scilit:
- Isolation and characterization of different molecular and chromatographic forms of heparin-binding growth factor 1 from bovine brainAnalytical Biochemistry, 1987
- TGF-β inhibition of endothelial cell proliferation: Alteration of EGF binding and EGF-induced growth-regulatory (competence) gene expressionCell, 1987
- [35] Kinetic analysis of cell growth factor-nutrient interactionsPublished by Elsevier ,1987
- Complete primary structure of prostatropin, a prostate epithelial cell growth factorBiochemistry, 1986
- Human Endothelial Cell Growth Factor: Cloning, Nucleotide Sequence, and Chromosome LocalizationScience, 1986
- Nucleotide Sequence of a Bovine Clone Encoding the Angiogenic Protein, Basic Fibroblast Growth FactorScience, 1986
- REVERSIBLE INHIBITION OF NORMAL HUMAN PROKERATINOCYTE PROLIFERATION BY TYPE-BETA TRANSFORMING GROWTH FACTOR-GROWTH INHIBITOR IN SERUM-FREE MEDIUM1986
- Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells.Proceedings of the National Academy of Sciences, 1986
- DNA synthesis in rat hepatocytes: Inhibition by a platelet factor and stimulation by an endogenous factorJournal of Cellular Physiology, 1985
- DIRECT MITOGENIC EFFECTS OF INSULIN, EPIDERMAL GROWTH-FACTOR, GLUCOCORTICOID, CHOLERA-TOXIN, UNKNOWN PITUITARY FACTORS AND POSSIBLY PROLACTIN, BUT NOT ANDROGEN, ON NORMAL RAT PROSTATE EPITHELIAL-CELLS IN SERUM-FREE, PRIMARY-CELL CULTURE1984