Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation
- 1 May 1993
- journal article
- Published by Springer Nature in Nature
- Vol. 363 (6424) , 45-51
- https://doi.org/10.1038/363045a0
Abstract
The proteins Grb2-Sem-5, Shc and Sos have been implicated in the signalling pathway from tyrosine kinase receptors to Ras. Grb2-Sem-5 binds directly to murine Sos1, a Ras exchange factor, through two SH3 domains. Sos is also associated with ligand-activated tyrosine kinase receptors which bind Grb2-Sem-5, and with the Grb2-Sem-5 binding protein, Shc. Ectopic expression of Drosophila Sos stimulates morphological transformation of rodent fibroblasts. These data define a pathway by which tyrosine kinases act through Ras to control cell growth and differentiation.Keywords
This publication has 43 references indexed in Scilit:
- Identification of a Ten-Amino Acid Proline-Rich SH3 Binding SiteScience, 1993
- SH2 and SH3 domains: From structure to functionCell, 1992
- Growth factor signaling by receptor tyrosine kinasesNeuron, 1992
- Molecular cloning of cDNAs encoding the GAP-associated protein p190: Implications for a signaling pathway from ras to the nucleusCell, 1992
- Signal transduction and the fate of the R7 photoreceptor in DrosophilaTrends in Genetics, 1991
- Signal transduction during C. elegans vulval inductionTrends in Genetics, 1991
- Regulation of p21ras activityTrends in Genetics, 1991
- The GTPase superfamily: conserved structure and molecular mechanismNature, 1991
- Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferaseGene, 1988
- ras GENESAnnual Review of Biochemistry, 1987