A Role for PPARin the Regulation of Cytokines in Immune Cells and Cancer
Open Access
- 12 June 2008
- journal article
- retracted article
- Published by Hindawi Limited in PPAR Research
- Vol. 2008, 1-12
- https://doi.org/10.1155/2008/961753
Abstract
Peroxisome proliferator-activated receptor 𝛾 (PPAR𝛾) is a ligand-activated transcription factor and a member of the nuclear receptor superfamily. PPAR𝛾 and its ligands appear to serve diverse biological functions. In addition to the well-studied effects of PPAR𝛾 on metabolism and cellular differentiation, abundant evidence suggests that PPAR𝛾 is an important regulator of the immune system and cancers. Since cytokines are not only key modulators of inflammation with pro- and anti-inflammatory functions but they also can either stimulate or inhibit tumor growth and progression, this review summarizes the role for PPAR𝛾 in the regulation of cytokine production and cytokine-mediated signal transduction pathways in immune cells and cancer.Funding Information
- National Cancer Institute (NO1-CO-12400)
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