Anticonvulsant Properties of Hydroxylamine and Elevation of Cerebral -Aminobutyric Acid in Cats.

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Abstract
Hydroxylamine when administered to immobilized cats in acute experiments in doses of 10-20 mg/kg markedly reduced the duration and spread of electrically induced after-discharges while increasing cerebral levels of gamma-aminobutyric acid. These findings increase the probability that a causal relationship may exist between the metabolism of gamma-aminobutyric acid in a particular cerebral area and its excitability.