Tert-Butyl Hydroperoxide-Induced Injury In Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs
- 1 April 1990
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 56 (02) , 171-174
- https://doi.org/10.1055/s-2006-960918
Abstract
Tert-butyl hydroperoxide induces in freshly isolated rat hepatocytes malonaldehyde formation and lacticodehydrogenase and aspartate aminotransferase leakage. This model, when adapted to crude extracts, permits the demonstration of both anti-lipoperoxidant and antihepatotoxic activity of reference products like quercetin and silymarin and plant extracts like Rosmarinus officinalis and Eschscholzia californica.Keywords
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