Studies on Filtrates from Cultures of a Psychrophylic Pseudomonas Sp. Which Inactivate Nonspecific Serum Inhibitors for Certain Hemagglutinating Viruses

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Abstract
Summary: Filtrates from cultures of a psychrophylic Pseudomonas sp. have been shown to contain an enzyme-like substance or substances which inactivate serum inhibitors of hemagglutination by echoviruses, reoviruses and adenoviruses. The filtrates had no effect on serum inhibitors for WEE and SLE viruses, and the effect on influenza virus inhibitors varied with different virus strains. Treatment of human sera with the filtrates was shown to be less detrimental than kaolin treatment to specific hemagglutination-inhibition and neutralizing antibodies. Concentrated filtrates possessed some destructive activity for erythrocyte receptors. Hemagglutinating antigens for the echoviruses, reoviruses, influenza A/PR8/34 and A2/Japan/305/57 viruses and WEE virus treated with the filtrates showed unchanged or elevated titers, whereas treatment of the SLE antigen inactivated its hemagglutinating activity.