THE DISTRIBUTION AND MOVEMENTS OF INORGANIC PHOSPHATE BETWEEN CELLS AND SERUM OF HUMAN BLOOD

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Abstract
Comparison of blood sera with transudates and with artificial ultrafiltrates reveals the presence in serum of variable proportions of nondiffusible phosphate. The membrane of the resting red blood cell appears to be impermeable to inorganic phosphate. Movements of this component seem to be linked with the metabolic processes concerned with the synthesis and breakdown of cellular organic phosphate esters. The cells may lose large quantities of inorganic phosphate without appreciable quantities of Na or K. Alkalinization of the blood promotes synthesis or delays breakdown of organic phosphate, but accelerates glycolysis. Acidification has an opposite effect on both processes.

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