Aging Effect on Stability and Eioavailability of Glibenclamide in Solid Dosage, Forms

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Abstract
Asing effect of some solid dosage form of glibenclamide, after storage at various storage conditions and accelerated temperatures for certain length of time, affected percentage degradation, physical. properties, in-vitro dissclution and in- vivo performances, has been, investigated and compared with the marketed tablets of Dionil®. The percentage degradation responding to accelerated conditions has been extrapolated by formal Arrhenius treatment. Fowever, maximum stability and highest shelf-life of direct compression, lactose tablets, followed by DionllR and then suppositories have been observed. The aging and elevation of temperature, adversely affected dissolution rate and indicated a decrease In bioavailability of glibenclamide based on Cmax, and Tmax and AUC.

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