Bacteriological effects of anti-pseudomonas aeruginosa chemotherapy in cystic fibrosis
- 1 September 1987
- journal article
- research article
- Published by Springer Nature in Infection
- Vol. 15 (5) , 403-406
- https://doi.org/10.1007/bf01647753
Abstract
Strains ofPseudomonas aeruginosa resistant to clinically relevant antibiotics (β-lactams, quinolones, aminoglycosides) were detectable in sputa of cystic fibrosis patients. Correlations betweenin vitro susceptibility and bacteriological resultsin vivo were demonstrated at a quantitative level.P. aeruginosa strains susceptible prior to antibiotic therapy were observed to become resistant towards each of the compounds used for treatment. We conclude that antibiotic therapy in cystic fibrosis has to be optimized by culture specific selection of the drugs and consecutive bacteriological follow-ups. In Sputa von Patienten mit Mukoviszidose ließen sich β-lactam-, 4-chinolon- und aminoglykosidresistente Stämme vonPseudomonas aeruginosa nachweisen. Korrelation zwischen derIn vitro-Empfindlichkeit gegenüber Antibiotika und Veränderungen in der Konzentration vonP. aeruginosa pro Gramm Sputum wurde erkennbar. Resistenzentwicklung unter Therapie trat gegenüber allen verwendeten Antibiotika auf. Voraussetzung für optimalen Effekt von Antibiotika ist auch bei Mukoviszidose die Kenntnis des Resistenzverhaltens der Erreger sowohl vor als auch während der Therapie.This publication has 4 references indexed in Scilit:
- High dose treatment with antibiotics in cystic fibrosis — A reappraisal with special reference to the pharmacokinetics of betalactams and new fluoroquinolones in adult CF-patientsInfection, 1987
- Kinetic parameters of amikacin in cystic fibrosis childrenInfection, 1987
- Pharmacokinetics of antibiotics in cystic fibrosis patients with particular reference to the bronchopulmonary tree (review)Infection, 1987
- Qualitative and quantitative microbiological analysis of sputa of 102 patients with cystic fibrosisInfection, 1987