Immunization and Arthritis

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Abstract
Arthritis has been reported as a rare complication after immunization with various vaccines. After the administration of rubella virus vaccine, arthritis has been a relatively frequent complication, particularly in adolescent girls and young women. In connection with intensive immunization, rheumatoid factor has been transiently observed in both animals and human beings. The immunopathological implications of this phenomenon are poorly understood. Caution is indicated as regards intensive immunization which may be connected with unknown hazards.