Hormone-Independent Persistent Changes in Reproductive Organs in Female Rats Induced by Early Postnatal Treatment with Androgen
- 1 January 1965
- journal article
- Published by Japan Academy in Proceedings of the Japan Academy
- Vol. 41 (4) , 310-315
- https://doi.org/10.2183/pjab1945.41.310
Abstract
In female rats given injections of large doses of testosterone propionate for 30 consecutive days from the day of birth, ovaries were greatly reduced in size, containing only a few small follicles. The epithelium was thickened and more or less mucified in the proximal part of vagina, stratified but neither mucified nor cornified in the middle part, and cornified in the distal part. The uterine epithelium was hypertrophied in some animals. Hypophysectomy evoked no perceptible changes in the ovaries, and hypophysectomy followed by ovariectomy and adrenalectomy did not exert any influence on the uteri and vaginae. It seems highly probable that in these animals the secretion of gonadotropins from the anterior hypophysis was held in abeyance and that changes in the genital tract was irreversible and independent of stimulation by sex steroids.Keywords
This publication has 1 reference indexed in Scilit:
- Persistent Changes in Uterus and Vagina in Rats Given Injections of Estrogen for the First Thirty Postnatal DaysProceedings of the Japan Academy, 1964