Circadian changes in estimated hepatic blood flow in healthy subjects.
Open Access
- 1 November 1991
- journal article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 32 (5) , 627-629
- https://doi.org/10.1111/j.1365-2125.1991.tb03964.x
Abstract
Intravenous injections of indocyanine green (ICG) were given to 10 healthy supine subjects at 02.00, 08.00, 14.00 and 20.00 h. ICG plasma half-life, plasma clearance and estimated hepatic blood flow (EHBF), but not volume of distribution, varied significantly with time of day with EHBF being greatest at 08.00 h. This circadian rhythm in EHBF should be considered when evaluating the kinetics of high-clearance drugs at different times of day.Keywords
This publication has 10 references indexed in Scilit:
- Chronopharmacokinetics and Chronopharmacodynamics of Cardiovascular Active DrugsAnnals of the New York Academy of Sciences, 1991
- PHARMFIT—a Nonlinear Fitting Program for PharmacologyChronobiology International, 1991
- Chronopharmacology of oral nifedipine in healthy subjects and in hypertensive patientsEuropean Journal of Pharmacology, 1990
- Circadian changes in the pharmacokinetics and cardiovascular effects of oral propranolol in healthy subjectsEuropean Journal of Clinical Pharmacology, 1988
- Food effects on propranolol systemic and oral clearance: Support for a blood flow hypothesisClinical Pharmacology & Therapeutics, 1986
- Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects.Published by Wiley ,1984
- Effect of food on hepatic blood flow: Implications in the “food effect” phenomenonClinical Pharmacology & Therapeutics, 1983
- Physiological and pharmacological variability in estimated hepatic blood flow in man.Published by Wiley ,1981
- USE OF INDOCYANINE GREEN IN MEASUREMENT OF HEPATIC BLOOD FLOW AND AS A TEST OF HEPATIC FUNCTION1961