?-Type I Myeloma and Xanthomatosis

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Abstract
In multiple myeloma the concentration of serum lipoproteins is usually decreased.1,10 In a few patients, lipoproteins are markedly increased.11-16 Franklin et al27 have examined two patients with γ-type myeloma of type I specificity associated with hyperlipoidemia. In these, elevation of cholesterol and/ or lipoproteins due to the fortuitous occurrence of thyroid or renal diseases 25 or diabetes mellitus must be considered. Recently, several cases of myeloma associated with xanthomatosis have been reported.1,17-23 We have had under observation a man with xanthomatous myeloma, splenomegaly, absence of osteolytic lesions, and the presence of an "M"-protein in the γglobulin range on serum paper electrophoresis. Attempts to correlate the various immunological types of myeloma (γ-, γ2-A, and γmicron-, or Bence Jones)1,2 with clinical manifestations suggested the existence of a subtype of γ2-A-myeloma associated with xanthomatosis.1,3 Xanthomatous myeloma, however, is not specifically associated with abnormal β2-A-globulin as demonstrated by the following patient.

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