6-SULPHANILAMIDOINDAZOLE-INDUCED ARTHRITIS IN RATS - SUBSTANCE EFFECTS AND ACUTE-PHASE REACTION

  • 1 January 1986
    • journal article
    • research article
    • Vol. 8  (6) , 469-473
Abstract
Arthritis induced by 6-sulfanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferroxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAl arthritis. C-reactive protein and ceruloplasmin are demonstrated to be acute-phase reactants also in 6-SAl arthritis, although on the whole the acute-phase reaction is relatively weak. The steroid dexamethasone and the nonsteroid benoxaprofen caused strong antiinflammatory activity at low doses. The data presented complete the picture of 6-SAl arthritis as a special inflammatory reaction in rats.