Reverse Transcriptase-Mediated Tropism Switching in Bordetella Bacteriophage
- 15 March 2002
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 295 (5562) , 2091-2094
- https://doi.org/10.1126/science.1067467
Abstract
Host-pathogen interactions are often driven by mechanisms that promote genetic variability. We have identified a group of temperate bacteriophages that generate diversity in a gene, designatedmtd (major tropism determinant), which specifies tropism for receptor molecules on host Bordetella species. Tropism switching is the result of a template-dependent, reverse transcriptase–mediated process that introduces nucleotide substitutions at defined locations within mtd. This cassette-based mechanism is capable of providing a vast repertoire of potential ligand-receptor interactions.Keywords
This publication has 11 references indexed in Scilit:
- RNA editing by base deamination: more enzymes, more targets, new mysteriesTrends in Biochemical Sciences, 2001
- Diversity in the Bordetella virulence regulon: transcriptional control of a Bvg‐intermediate phase geneMolecular Microbiology, 2001
- Identification and characterization of BipA, a Bordetella Bvg‐intermediate phase proteinMolecular Microbiology, 2001
- Group II introns in the bacterial worldMolecular Microbiology, 2000
- A mutation in the Bordetella bronchiseptica bvgS gene results in reduced virulence and increased resistance to starvation, and identifies a new class of Bvg‐regulated antigensMolecular Microbiology, 1997
- Unusual Reverse TranscriptasesPublished by Elsevier ,1995
- Ectopic expression of the flagellar regulon alters development of the bordetella-host interactionCell, 1995
- Importance of purine and pyrimidine content of local nucleotide sequences (six bases long) for evolution of the human immunodeficiency virus type 1.Proceedings of the National Academy of Sciences, 1991
- Pertactin, an Arg-Gly-Asp-containing Bordetella pertussis surface protein that promotes adherence of mammalian cells.Proceedings of the National Academy of Sciences, 1991