Infection of Mice with Types I and HI Poliomyelitis Virus Following Intracerebral Inoculation

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Abstract
The type I and III strains of poliomyelitis adapted to mice by the intraspinal route by Li and Habel and Li and Schaeffer were infective by the intracerebral route for the Prince Henry mice in Australia. Examination of the behavior of the type I strain during the first 12 passages in Prince Henry mice revealed that there was a slight increase in virulence resulting in more than 50% of the animals becoming paralyzed with an avg. incubation period of 3 days. Nearly every infected mouse was paralyzed in the fore-limbs only. The virus was found in highest concn. in the cervico-thoracic area of the cord, but was demonstrated in lower concn. in lumbar cord and brain. Monkeys remained asymptomatic following intracerebral inoculation with this strain.

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