Adaptation of Type I Poliomyelitis Virus to Mice

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Abstract
The procedures employed in the successful adaptation of Type I (Mahoney) poliomyelitis virus to Swiss mice are described. This virus could also infect hamsters and C3H mice but not cotton rats, and its original virulence for monkeys was lost. The use of the intraspinal route of inoculation and the selection of a mutant or variant of the virus is probably responsible for this adaptation. Other possible explanations are discussed. With this attainment, all 3 poliomyelitis virus types have been adapted to mice. This will permit more rapid progress in field and laboratory studies of poliomyelitis.