Dopamine Receptor Binding Enhancement Accompanies Lesion-Induced Behavioral Supersensitivity
- 5 August 1977
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 197 (4303) , 596-598
- https://doi.org/10.1126/science.877576
Abstract
The binding of [3H]haloperidol to rat striatal dopamine receptors increases after lesion (made by injection of 6-hydroxydopamine) of the nigrostriatal dopamine pathway in those rats which are behaviorally supersensitive, as reflected by apomorphine-induced contralateral rotations. The enhanced binding is associated with an increased number of receptor sites with no change in their affinity.This publication has 21 references indexed in Scilit:
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