Prognostic Significance of Partial Tandem Duplications of the MLL Gene in Adult Patients 16 to 60 Years Old With Acute Myeloid Leukemia and Normal Cytogenetics: A Study of the Acute Myeloid Leukemia Study Group Ulm
Top Cited Papers
- 1 August 2002
- journal article
- clinical trial
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 20 (15) , 3254-3261
- https://doi.org/10.1200/jco.2002.09.088
Abstract
PURPOSE: To evaluate the incidence and clinical significance of partial tandem duplications (PTDs) of the mixed lineage leukemia (MLL) gene in a large series of newly diagnosed adult patients (16 to 60 years old) with acute myeloid leukemia (AML) intensively treated within the multicenter treatment trials AML-HD93 and AML-HD98A.Keywords
This publication has 24 references indexed in Scilit:
- Clinical importance of cytogenetics in acute myeloid leukaemiaBest Practice & Research Clinical Haematology, 2001
- Karyotypic analysis predicts outcome of preremission and postremission therapy in adult acute myeloid leukemia: a Southwest Oncology Group/Eastern Cooperative Oncology Group studyBlood, 2000
- Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AMLLeukemia, 2000
- Core-binding factor (CBF) and MLL-associated primary acute myeloid leukemia: biology and clinical implicationsAnnals of Hematology, 1999
- The Importance of Diagnostic Cytogenetics on Outcome in AML: Analysis of 1,612 Patients Entered Into the MRC AML 10 TrialBlood, 1998
- Partial Tandem Duplications of the MLL Gene Are Detectable in Peripheral Blood and Bone Marrow of Nearly All Healthy DonorsBlood, 1998
- The partial tandem duplication of ALL1 ( MLL ) is consistently generated by Alu- mediated homologous recombination in acute myeloid leukemiaProceedings of the National Academy of Sciences, 1998
- The partial tandem duplication of ALL1 in acute myeloid leukemia with normal cytogenetics or trisomy 11 is restricted to one chromosomeProceedings of the National Academy of Sciences, 1997
- Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal TranslocationsNew England Journal of Medicine, 1993
- The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 geneCell, 1992