REVERSAL OF d -CYCLOSERINE INHIBITION OF BACTERIAL GROWTH BY ALANINE

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Abstract
Zygmunt, Walter A. (Mead Johnson & Co., Evansville, Ind.). Reversal of d -cycloserine inhibition of bacterial growth by alanine. J. Bacteriol. 84: 154–156. 1962.—Reversal of the antibacterial activity of d -4-amino-3-isoxazolidone by alanine in bacterial cultures actively growing on chemically defined media was compared in cultures requiring exogenous alanine and those capable of its synthesis. dl -Alanine was the most effective reversal agent in Pediococcus cerevisiae , an alanine-requiring organism, and d -alanine was effective in Escherichia coli and Staphylococcus aureus , organisms synthesizing alanine. With all three cultures, l -alanine was the least effective reversal agent.