T‐cell transfer and cytokine/TCR gene deletion models in the study of inflammatory bowel disease
- 1 July 1997
- Vol. 105 (7-12) , 655-662
- https://doi.org/10.1111/j.1699-0463.1997.tb05068.x
Abstract
Until recently there existed no appropriate immunological animal models for human inflammatory bowel diseases (IBD). Today a number of models, mostly in the mouse and rat, have proved useful in the study of several aspects of IBD, including the histopathology and the disease-inductive and -protective cell types, subsets and cytokines, for example CD4+ T cells, IFNΛ, IL-12, IL-2, IL-10 and TGFβ. Furthermore, these recent IBD models make it possible to examine various chemo- and immunotherapeutic approaches. This review focuses on IBD development in adoptive T-cell transfer models and in gene-deleted mice.Keywords
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