ERYTHEMA MULTIFORME EXUDATIVUM (STEVENS-JOHNSON SYNDROME)

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Abstract
The purpose of this presentation is to report a case of Stevens-Johnson syndrome (severe erythema multiforme), treated with pituitary adrenocorticotropic hormone, in which healing was rapidly effected and the symptomatic response to therapy was considered spectacular. The case conformed to the syndrome described by Stevens and Johnson1a and presented (1) generalized toxicity, (2) erythema multiformelike skin eruption, (3) purulent ophthalmia, (4) ulcerative stomatitis, and (5) an ulcerative lesion of the urethral meatus. The cause of erythema multiforme exudativum has not been definitely established. Review of the literature1 indicates that the disease may be infectious, although a common bacterial agent has not been found. Drug ingestion as a cause has been investigated, but most patients, including our own, do not give a history of drug ingestion. The possibility of a virus as the causative factor has also been investigated. Anderson, Bolin, Sutow, and Kitto2 isolated cytoplasmic inclusion bodies

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