The effects of dietary supplementation with n‐3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial

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Abstract
Study objective: To determine the effect of dietary supplementation with n‐3 polyunsaturated fatty acids (n‐3 PUFA) on disease variables in patients with rheumatoid arthritis. Design: Multicenter, randomized, placebo controlled, double blind. Setting: Three Danish hospital Departments of Rheumatology. Patients: Fifty‐one patients with active rheumatoid arthritis. Intervention: Random allocation to 12 weeks of treatment with either six n‐3 PUFA capsules (3–6 g) or six capsules with fat composition as the average Danish diet. Main results: Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects. Conclusions: Dietary supplementation with n‐3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n‐3 PUFA in the treatment of rheumatoid arthritis.

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