Protozoa as Pharmacological Tools: The Antihistamines
- 1 August 1959
- journal article
- research article
- Published by Microbiology Society in Journal of General Microbiology
- Vol. 21 (1) , 264-270
- https://doi.org/10.1099/00221287-21-1-264
Abstract
Two protozoa, Ochromonas malhamensis and Tetrahymena pyriformis, were used to study the mode of action and side effects of three antihistamines: diphenhydramine, tripelennamine and pheniramine. The mode of action was studied by inhibition analysis and the side effects by motility tests. The use of these methods as preliminary screening procedures for new chemotherapeutic agents is discussed.Keywords
This publication has 2 references indexed in Scilit:
- Inhibition of Growth of a Green Flagellate by the Antihistamine, -dimethylaminoethyl (Benadryl).Experimental Biology and Medicine, 1952
- Influence of Histamine upon Fungistatic Action of AntihistaminicsExperimental Biology and Medicine, 1951