The α‐Synucleinopathies: Parkinson's Disease, Dementia with Lewy Bodies, and Multiple System Atrophy
Top Cited Papers
- 1 December 2000
- journal article
- review article
- Published by Wiley in Annals of the New York Academy of Sciences
- Vol. 920 (1) , 16-27
- https://doi.org/10.1111/j.1749-6632.2000.tb06900.x
Abstract
Abstract:Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease. Neuropathologically, it is characterized by the degeneration of populations of nerve cells that develop filamentous inclusions in the form of Lewy bodies and Lewy neurites. Recent work has shown that the filamentous inclusions of Parkinson's disease are made of the protein α‐synuclein and that rare, familial forms of Parkinson's disease are caused by missense mutations in the α‐synuclein gene. Besides Parkinson's disease, the filamentous inclusions of two additional neurodegenerative diseases, namely, dementia with Lewy bodies and multiple system atrophy, have also been found to be made of α‐synuclein. Recombinant α‐synuclein has been shown to assemble into filaments with similar morphologies to those found in the human diseases and with a cross‐β fiber diffraction pattern. The new work has established the α‐synucleinopathies as a major class of neurodegenerative disease.Keywords
This publication has 72 references indexed in Scilit:
- Microtubule-associated protein tau, heparan sulphate and α-synuclein in several neurodegenerative diseases with dementiaActa Neuropathologica, 1999
- Antibodies to ?-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's diseaseAnnals of Neurology, 1999
- Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein GenesPublished by Elsevier ,1998
- α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson’s disease and dementia with Lewy bodiesProceedings of the National Academy of Sciences, 1998
- α-Synuclein in Lewy bodiesNature, 1997
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997
- Neuropathology of Parkinsonʼs DiseaseJournal of Neuropathology and Experimental Neurology, 1996
- The Lewy body variant of Alzheimer's diseaseNeurology, 1990
- Lewy bodies in cerebral cortex. Report of three casesActa Neuropathologica, 1978
- PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASEJournal of Neuropathology and Experimental Neurology, 1965