Antibodies to ?-synuclein detect Lewy bodies in many Down's syndrome brains with Alzheimer's disease
- 1 March 1999
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 45 (3) , 353-357
- https://doi.org/10.1002/1531-8249(199903)45:3<353::aid-ana11>3.0.co;2-4
Abstract
Immunohistochemical examination of 20 Down's syndrome brains, using antibodies to α‐, β‐, and γ‐synuclein, demonstrated many α‐synuclein–positive Lewy bodies and dystrophic neurites in 50% of amygdala samples from Down's syndrome brains with Alzheimer's disease. Similar lesions were less common in other regions of these brains, none of which contained β‐synuclein or γ‐synuclein abnormalities. Thus, α‐synuclein–positive Lewy bodies and neuritic processes frequently occur with Alzheimer's disease in Down's syndrome brains. Ann Neurol 1999;45:353–357Keywords
This publication has 20 references indexed in Scilit:
- Lewy Bodies Contain Altered α-Synuclein in Brains of Many Familial Alzheimer's Disease Patients with Mutations in Presenilin and Amyloid Precursor Protein GenesPublished by Elsevier ,1998
- Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synucleinAnnals of Neurology, 1998
- AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's diseaseNature Genetics, 1998
- Consensus Recommendations for the Postmortem Diagnosis of Alzheimer’s DiseaseNeurobiology of Aging, 1997
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997
- Pattern of brain destruction in Parkinson's and Alzheimer's diseasesJournal Of Neural Transmission-Parkinsons Disease and Dementia Section, 1996
- Staging of alzheimer's disease-related neurofibrillary changesNeurobiology of Aging, 1995
- Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down SyndromeAnnals of Neurology, 1995
- A pathological study of the association between Lewy body disease and Alzheimer's disease.Journal of Neurology, Neurosurgery & Psychiatry, 1989
- Anti-ubiquitin immunocytochemistry is more sensitive than conventional techniques in the detection of diffuse Lewy body disease.Journal of Neurology, Neurosurgery & Psychiatry, 1989