LOCAL ANTI-INFLAMMATORY ACTIVITY OF ACID ESTER DERIVATIVES OF PREDNISOLONE

  • 1 January 1981
    • journal article
    • research article
    • Vol. 33  (2) , 357-360
Abstract
The antiinflammatory activity of 2 steroid acid esters, methyl prednisolonate and methyl 20-dihydroprednisolonate, synthesized by modifying the 17.beta. ketol side chain of prednisolone was investigated in the cotton pellet granuloma bioassay in rats. The inhibitory effect of the ester derivatives on granuloma formation was equivalent to that of the parent compound. At dose of 5 mg/cotton pellet, methyl prednisolonate exhibited a highly significant thymolytic effect comparable to that of prednisolone, while methyl 20-dihydroprednisolonate had a weaker thymolytic effect. The local antiinflammatory activity of the 2 esters was not accompanied by a decrease in adrenal weight observed with the parent compound.