The Relationship Between Pyridoxine Ingestion and Transaminase Activity I. Blood Hemolysates ,

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Abstract
The method of Tonhazy et al. for the estimation of aspartic-glutamic transaminase has been adapted to the measurement of the enzyme in whole blood. A study was made of the transaminase and vitamin B6 levels of the blood of monkeys receiving graded doses of pyridoxine hydrochloride and also of humans receiving extradietary supplements of pyridoxine hydrochloride. In both monkeys and man, increasing the intake of pyridoxine resulted in significant increases in the blood level of the transaminase and of the vitamin B6. Reductions in the pyridoxine intake were followed by a lowering of the blood concentration of both factors. The changes in the level of transaminase were often more gradual, however, than were those of vitamin B6. The time required to reduce the levels to a minimum after withdrawal of all pyridoxine or to the initial levels after the supplemental dosage was discontinued seemed to be dependent to some extent upon the duration of the period of the increased intake.