Structure and Variability of the a Sequence in the Genome of Human Cytomegalovirus (Towne Strain)
- 1 August 1987
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 68 (8) , 2223-2230
- https://doi.org/10.1099/0022-1317-68-8-2223
Abstract
Summary We have defined the boundaries of the a sequence from human cytomegalovirus (CMV) strain Towne, characterized internal variability and determined the position of the cleavage site used to generate genomic termini. The cleavage site is positioned a fixed distance from two stretches of sequence homology that have been observed near the ends of many herpesvirus genomes. Unlike a comparable region in CMV (AD169), the CMV (Towne) a sequence has a relatively low level of variability within the a sequence and its structure is stable through repeated virus passage.Keywords
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