PROTEOLYSIS OF HUMAN-IGG BY HUMAN POLYMORPHONUCLEAR LEUKOCYTE ELASTASE PRODUCES AN FC-FRAGMENT WITH INVITRO BIOLOGICAL-ACTIVITY

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  • 1 January 1979
    • journal article
    • research article
    • Vol. 37  (1) , 162-168
Abstract
The Fc fragment derived by proteolysis of human Ig[immunoglobulin]G by human polymorphonuclear leukocyte (PMN) elastase was tested for in vitro biological activity. This fragment could attach to the specific IgG receptor of Staphylococcus aureus Cowan I cells (protein A) and could be eluted from the cells with dissociating buffer. The Fc fragment was capable of attaching to the antigen-combining site of an IgM rheumatoid factor and can bind to the Fc receptor of human PMN. A similar fragment produced in vivo at sites of inflammation could play a role in regulating the inflammatory response.