Genetic evidence that a Y-linked gene in man is homologous to a gene on the X chromosome
- 1 March 1983
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 302 (5906) , 346-349
- https://doi.org/10.1038/302346a0
Abstract
The mammalian sex chromosomes are thought to be related to each other by sharing a common origin. That is, the X and Y chromosomes originally evolved from a pair of chromosomes that only differed at the locus determining sexual differentiation1,2. For example, this evolutionary relationship is reflected during meiosis3 in chromosomal pairing between the tip of the human X chromosome short arm and the Y chromosome which presumably implies sequence homology4. However, compelling genetic evidence for functional homology between the mammalian X and Y chromosome is lacking. We describe here the localization of a gene to the tip of the short arm of the human X chromosome and evidence for a related gene on the Y chromosome.Keywords
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