Expression of Synaptophysin During Postnatal Development of the Mouse Brain
- 5 October 1986
- journal article
- research article
- Published by Wiley in Journal of Neurochemistry
- Vol. 47 (4) , 1302-1304
- https://doi.org/10.1111/j.1471-4159.1986.tb00754.x
Abstract
The expression of the synaptic vesicle membrane protein, synaptophysin, was analyzed during postnatal development of the mouse cerebrum using a quantitative immunoblotting procedure. From birth to adulthood, the relative contents of synaptophysin increased 80-fold, reaching a final level of 3.5 μg/mg of total protein. The time course of accumulation suggests that synaptophysin expression is correlated with synaptogenesis. Thus synaptophysin may be used as a reliable marker of nerve terminal differentiation.Keywords
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